PICK1

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

Protein Interacting With PRKCA 1

Function

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Biological Process

Cellular response to decreased oxygen levelsISS:UniProtKB
Cellular response to glucose starvationISS:UniProtKB
Dendritic spine maintenanceISS:UniProtKB
Dendritic spine organizationISS:UniProtKB
DNA methylation involved in embryo development1 PublicationNAS:UniProtKB
DNA methylation involved in gamete generationManual Assertion Based On ExperimentTAS:UniProtKB
Glial cell developmentISS:UniProtKB
Intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Long-term synaptic depressionISS:UniProtKB
Monoamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of Arp2/3 complex-mediated actin nucleationISS:UniProtKB
Neuronal ion channel clusteringManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of receptor internalizationISS:UniProtKB
Protein kinase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationISS:UniProtKB
Receptor clusteringISS:UniProtKB
Regulation of Arp2/3 complex-mediated actin nucleationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of insulin secretionManual Assertion Based On ExperimentIMP:FlyBase
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm, perinuclear region
Membrane
Membrane
Cell junction, synapse, postsynaptic density
Cell junction, synapse, synaptosome
Cytoplasm, cytoskeleton
Also membrane-associated, present at excitatory synapses.

PTM

Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).