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POLR1C

POLR1C is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11.

Full Name

polymerase (RNA) I polypeptide C, 30kDa

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Biological Process

Transcription by RNA polymerase IManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus

Involvement in disease

Treacher Collins syndrome 3 (TCS3):
A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss.
Leukodystrophy, hypomyelinating, 11 (HLD11):
An autosomal recessive neurologic disorder characterized by brain hypomyelination, delayed psychomotor development, intellectual disability, tremor and other neurologic symptoms. Some patients may additionally manifest non-neurologic features, particularly dental abnormalities and hypogonadotropic hypogonadism.

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Anti-POLR1C antibodies

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Mouse Anti-POLR1C Recombinant Antibody (2E11) (CBMAB-A6865-LY)

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Target: POLR1C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E11

Application*: WB, E

Mouse Anti-POLR1C Recombinant Antibody (CBYC-P501) (CBMAB-P2343-YC)

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Target: POLR1C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYC-P501

Application*: E, IF, IH, WB

Mouse Anti-POLR1C Recombinant Antibody (M1) (CBMAB-P2342-YC)

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Target: POLR1C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: M1

Application*: E, P, WB

Mouse Anti-POLR1C Recombinant Antibody (3A5-H2) (CBMAB-P2341-YC)

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Target: POLR1C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3A5-H2

Application*: IF, WB

Mouse Anti-POLR1C Recombinant Antibody (2A5-A5) (CBMAB-P2340-YC)

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Target: POLR1C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2A5-A5

Application*: E, IF, WB

Mouse Anti-POLR1C Recombinant Antibody (5E173) (CBMAB-R0626-CN)

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Target: POLR1C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5E173

Application*: E, IF, IH, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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