PON2

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
Full Name
Paraoxonase 2
Function
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
Biological Process
Aromatic compound catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Response to oxidative stressIEA:Ensembl
Response to toxic substanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
PTM
The signal sequence is not cleaved.
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Anti-PON2 antibodies

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Mouse Anti-PON2 Recombinant Antibody (CBXS-0059) (CBMAB-S3060-CQ)

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Target: PON2
Host: Mouse
Specificity: Human
Clone: CBXS-0059
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-PON2 Recombinant Antibody (AF3E6) (CBMAB-0682CQ)

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Target: PON2
Host: Mouse
Antibody Isotype: IgG, κ
Specificity: Human
Clone: AF3E6
Application*: F, IP, WB
Datasheet SDS

Rabbit Anti-PON2 Recombinant Antibody (BA0147) (CBMAB-0681CQ)

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Target: PON2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0147
Application*: IF, IP, WB
Datasheet SDS

Rabbit Anti-PON2 Recombinant Antibody (BA0146) (CBMAB-0680CQ)

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Target: PON2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0146
Application*: WB, P, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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