POU2F2

POU2F2 is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters.

Full Name

POU class 2 homeobox 2

Function

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290).
Regulates IL6 expression in B cells with POU2AF1 (By similarity).
Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654).
Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874).
Isoform 5
Activates the U2 small nuclear RNA (snRNA) promoter.

Biological Process

Cellular response to virusISS:UniProtKB
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-6 productionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus

Anti-POU2F2 antibodies

Rabbit Anti-POU2F2 Recombinant Antibody (CBCNC-686) (CBMAB-C4136-CN)

Datasheet

SDS

Target: POU2F2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNC-686

Application*: E

Mouse Anti-POU2F2 Recombinant Antibody (MRQ-2) (CBMAB-P2436-YC)

Datasheet

SDS

Target: POU2F2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MRQ-2

Application*: C, P

Mouse Anti-POU2F2 Recombinant Antibody (CBXO-0493) (CBMAB-O0264-CQ)

Datasheet

SDS

Target: POU2F2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0493

Application*: IH

Mouse Anti-POU2F2 Recombinant Antibody (CBXO-0538) (CBMAB-O0263-CQ)

Datasheet

SDS

Target: POU2F2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0538

Application*: E, IH, WB

Datasheet

SDS

Target: POU2F2

Host: Mouse

Specificity: Human

Clone: IHC642

Application*: IH

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)