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PSMD5

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base. [provided by RefSeq]

Full Name

PSMD5

Function

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Biological Process

Proteasome regulatory particle assemblyManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

cytosol
nucleoplasm
proteasome accessory complex
proteasome complex

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Anti-PSMD5 antibodies

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Mouse Anti-PSMD5 Recombinant Antibody (1H7) (CBMAB-A7145-LY)

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Target: PSMD5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1H7

Application*: WB, E

Mouse Anti-PSMD5 Recombinant Antibody (CBYC-P716) (CBMAB-P3234-YC)

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Target: PSMD5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P716

Application*: E, IH, WB

Mouse Anti-PSMD5 Recombinant Antibody (3E2) (CBMAB-P3232-YC)

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Target: PSMD5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3E2

Application*: WB

PSMD5 Matched Antibody Pair (938) (APMAB-938LY)

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Target: PSMD5

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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