RFX3

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Full Name

Regulatory Factor X3

Function

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity).
Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032).
Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430).

Biological Process

Biological Process cell maturationBy SimilarityISS:BHF-UCL
Biological Process cilium assemblyBy SimilarityISS:BHF-UCL
Biological Process cilium-dependent cell motilityISS:UniProtKB
Biological Process endocrine pancreas developmentISS:UniProtKB
Biological Process epithelial cilium movement involved in determination of left/right asymmetryISS:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of type B pancreatic cell developmentBy SimilarityISS:BHF-UCL
Biological Process regulation of insulin secretionISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription, DNA-templatedISS:UniProtKB
Biological Process transcription, DNA-templatedIEA:Ensembl
Biological Process type B pancreatic cell maturationIEA:Ensembl

Cellular Location

Nucleus