RHBG

This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Full Name

Rh Family B Glycoprotein (Gene/Pseudogene)

Function

Functions as a specific ammonium transporter.

Biological Process

Biological Process ammonium homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ammonium transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transepithelial ammonium transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Basolateral cell membrane
Cytoplasmic vesicle membrane

Topology

Cytoplasmic: 1-13
Helical: 14-34
Extracellular: 35-61
Helical: 62-82
Cytoplasmic: 83-86
Helical: 87-107
Extracellular: 108-124
Helical: 125-145
Cytoplasmic: 146-149
Helical: 150-170
Extracellular: 171-178
Helical: 179-201
Cytoplasmic: 202-219
Helical: 220-240
Extracellular: 241-251
Helical: 252-272
Cytoplasmic: 273-282
Helical: 283-303
Extracellular: 304
Helical: 305-325
Cytoplasmic: 326-346
Helical: 347-367
Extracellular: 368-393
Helical: 394-414
Cytoplasmic: 415-458

PTM

N-glycosylated.