RPRD1B

RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B) is a Protein Coding gene. Diseases associated with RPRD1B include Retroperitoneal Leiomyosarcoma. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes. Gene Ontology (GO) annotations related to this gene include RNA polymerase II core binding. An important paralog of this gene is RPRD1A.

Full Name

Regulation Of Nuclear Pre-MRNA Domain Containing 1B

Function

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.

Biological Process

Biological Process dephosphorylation of RNA polymerase II C-terminal domainManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mRNA 3'-end processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell cycle processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus