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RPS6

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Full Name

ribosomal protein S6

Function

Component of the 40S small ribosomal subunit (PubMed:8706699).
Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279).

Biological Process

Activation-induced cell death of T cellsIEA:Ensembl
Cytoplasmic translation1 PublicationIC:FlyBase
Erythrocyte developmentIEA:Ensembl
G1/S transition of mitotic cell cycleIEA:Ensembl
GastrulationIEA:Ensembl
Glucose homeostasisISS:UniProtKB
Mammalian oogenesis stageIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Placenta developmentIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal small subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
T cell differentiation in thymusIEA:Ensembl
T cell proliferation involved in immune responseIEA:Ensembl
TOR signalingManual Assertion Based On ExperimentIDA:UniProtKB
Translation2 PublicationsIC:UniProtKB

Cellular Location

cell body
cytoplasm
cytoplasmic ribonucleoprotein granule
cytosol
cytosolic ribosome
cytosolic small ribosomal subunit
dendrite
endoplasmic reticulum
membrane
nucleolus
nucleoplasm
nucleus
perinuclear region of cytoplasm
polysome
ribonucleoprotein complex
small ribosomal subunit

PTM

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.
Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.

Anti-RPS6 antibodies

Rabbit Anti-RPS6 (phosphorylated Ser235) Recombinant Antibody (4H372) (PTM-CBMAB-R4205-CN)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: 4H372

Application*: WB

Rabbit Anti-RPS6 (phosphorylated Ser235) Recombinant Antibody (9H270) (PTM-CBMAB-R4206-CN)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 9H270

Application*: WB

Rabbit Anti-RPS6 (phosphorylated Ser235) Recombinant Antibody (CBCNR-912) (PTM-CBMAB-R4207-CN)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNR-912

Application*: WB, IP, P, IF

Rabbit Anti-RPS6 (phosphorylated Ser235) Recombinant Antibody (MC27) (PTM-CBMAB-R4208-CN)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: MC27

Application*: WB

Rabbit Anti-RPS6 (phosphorylated Ser240/Ser244) Recombinant Antibody (SP45) (PTM-CBMAB-R4209-CN)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: SP45

Application*: IH, P

Rabbit Anti-RPS6 (phosphorylated Ser235/Ser236) Recombinant Antibody (SP50) (PTM-CBMAB-R4210-CN)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: SP50

Application*: IH, P

Mouse Anti-RPS6 Recombinant Antibody (522731) (CBMAB-R0299-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 522731

Application*: WB, ICC

Rabbit Anti-RPS6 Recombinant Antibody (CBXS-6142) (CBMAB-S6301-CQ)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Pig, Rat

Clone: CBXS-6142

Application*: IC, IF, P, WB

Mouse Anti-RPS6 Recombinant Antibody (CBXS-3478) (CBMAB-S6208-CQ)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse, Rat

Clone: CBXS-3478

Application*: F, IF, IH, IP, WB

Mouse Anti-RPS6 Recombinant Antibody (CBXS-6136) (CBMAB-S3003-CQ)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Fruit fly, Human, Mouse, Rat

Clone: CBXS-6136

Application*: F, IC, IF, P, WB

Rabbit Anti-RPS6 Recombinant Antibody (CBXS-5767) (CBMAB-S0627-CQ)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Pig

Clone: CBXS-5767

Application*: WB, P, IF

Mouse Anti-RPS6 Recombinant Antibody (CBXS-5720) (CBMAB-S0462-CQ)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Monkey

Clone: CBXS-5720

Application*: WB, P, IF, F

Rabbit Anti-RPS6 Recombinant Antibody (CBXS-5983) (CBMAB-S0297-CQ)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Dog, Human

Clone: CBXS-5983

Application*: CI, F, IC, IF, WB

Rabbit Anti-RPS6 (Phosphorylated S235/S236) Recombinant Antibody (2F9) (PTM-CBMAB-0048LY)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Monkey, Human, Mouse, Rat

Clone: 2F9

Application*: IF, FC

Rabbit Anti-RPS6 (Phosphorylated S240/S244) Recombinant Antibody (D68F8) (PTM-CBMAB-0140LY)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Chicken, Pig

Clone: D68F8

Application*: FC

Rabbit Anti-RPS6 (Phosphorylated S235/S236) Recombinant Antibody (5i128(2F9)) (PTM-CBMAB-0429LY)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 5i128(2F9)

Application*: FC, IC, IF, WB

Rabbit Anti-RPS6 (Phosphorylated S235/S236) Recombinant Antibody (5i129(91B2)) (PTM-CBMAB-0430LY)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 5i129(91B2)

Application*: IH, IP, WB

Rabbit Anti-RPS6 (Phosphorylated S235/S236) Recombinant Antibody (8A31(D57.2.2E)) (PTM-CBMAB-0494LY)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: 8A31(D57.2.2E)

Application*: FC, IF

Rabbit Anti-RPS6 (Phosphorylated S235/S236) Recombinant Antibody (91B2) (PTM-CBMAB-0500LY)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 91B2

Application*: WB, P, C, IF

Rabbit Anti-RPS6 Recombinant Antibody (5G10) (CBMAB-CP2342-LY)

SDS

Target: RPS6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Pig

Clone: 5G10

Application*: WB, P, IF, IF (IC)

Mouse Anti-RPS6 Recombinant Antibody (2H7) (CBMAB-BR435LY)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse

Clone: 2H7

Application*: FC, IF, IHC-P, ICC, WB

Mouse Anti-RPS6 Recombinant Antibody (3H1-F2) (CBMAB-R3503-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3H1-F2

Application*: WB

rabbit Anti-RPS6 Recombinant Antibody (4i8'5G10) (CBMAB-R3504-CN)

SDS

Target: RPS6

Host: rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey, Mouse, Rat

Clone: 4i8'5G10

Application*: E, ICC, IF, IH, WB

Mouse Anti-RPS6 Recombinant Antibody (981CT2.1.1) (CBMAB-R3505-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: 981CT2.1.1

Application*: IH, WB, F, IF, E

Mouse Anti-RPS6 Recombinant Antibody (A16009C) (CBMAB-R3506-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: A16009C

Application*: WB

Mouse Anti-RPS6 Recombinant Antibody (CBCNR-767) (CBMAB-R3507-CN)

SDS

Target: RPS6

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: CBCNR-767

Application*: WB, IH, IF, F

Mouse Anti-RPS6 Recombinant Antibody (CBCNR-768) (CBMAB-R3508-CN)

SDS

Target: RPS6

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: CBCNR-768

Application*: WB, IH, IF, F

Mouse Anti-RPS6 Recombinant Antibody (CBCNR-769) (CBMAB-R3509-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBCNR-769

Application*: WB

Mouse Anti-RPS6 Recombinant Antibody (CBCNR-771) (CBMAB-R3511-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBCNR-771

Application*: WB

Mouse Anti-RPS6 Recombinant Antibody (CBCNR-772) (CBMAB-R3512-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-772

Application*: WB

Mouse Anti-RPS6 Recombinant Antibody (RB47985) (CBMAB-R3513-CN)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: RB47985

Application*: WB, P, IF

Mouse Anti-RPS6 Recombinant Antibody (54D2) (CBMAB-CP2343-LY)

SDS

Target: RPS6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Monkey, D. melanogaster

Clone: 54D2

Application*: WB, P, IF (IC), F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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