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RPS6KA2

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Full Name
ribosomal protein S6 kinase, 90kDa, polypeptide 2
Function
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Biological Process
Biological Process brain renin-angiotensin systemIEA:Ensembl
Biological Process cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process cellular response to carbohydrate stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionTAS:Reactome
Biological Process heart contractionIEA:Ensembl
Biological Process heart developmentIEA:Ensembl
Biological Process intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of meiotic nuclear divisionIEA:Ensembl
Biological Process oocyte maturationIEA:Ensembl
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of protein processingIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
PTM
Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
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Anti-RPS6KA2 antibodies

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Rabbit Anti-RPS6KA2 Recombinant Antibody (E202) (CBMAB-R3543-CN)

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Target: RPS6KA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: E202
Application*: WB, IP, P, ICC
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (CBCNR-773) (CBMAB-R3542-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNR-773
Application*: E, IF, P
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (5G2) (CBMAB-R3541-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5G2
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (3C8) (CBMAB-R3540-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C8
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (3C1) (CBMAB-R3539-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 3C1
Application*: E, WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (3A3) (CBMAB-R3538-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3A3
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (2H3) (CBMAB-R3537-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H3
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (2H10) (CBMAB-R3536-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H10
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (2D4) (CBMAB-R3535-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D4
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (1F6) (CBMAB-R3534-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F6
Application*: WB, E, IH, IF
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (10F11) (CBMAB-R3533-CN)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10F11
Application*: WB
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (3C4C8) (CBMAB-R0354-CN)

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Target: RPS6KA2
Host: Mouse
Specificity: Mouse, Human
Clone: 3C4C8
Application*: WB, IP, IF, P, F, E
Datasheet SDS

Mouse Anti-RPS6KA2 Recombinant Antibody (CBT4350) (V2LY-0625-LY212)

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Target: RPS6KA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT4350
Application*: WB, IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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