RXFP1

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Full Name

Relaxin/Insulin Like Family Peptide Receptor 1

Function

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.

Biological Process

Biological Process activation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process extracellular matrix organizationIEA:Ensembl
Biological Process hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lung connective tissue developmentIEA:Ensembl
Biological Process myofibroblast differentiationIEA:Ensembl
Biological Process nipple morphogenesisIEA:Ensembl
Biological Process parturitionIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-409
Helical: 410-430
Cytoplasmic: 431-443
Helical: 444-464
Extracellular: 465-486
Helical: 487-507
Cytoplasmic: 508-527
Helical: 528-548
Extracellular: 549-577
Helical: 578-598
Cytoplasmic: 599-629
Helical: 630-650
Extracellular: 651
Helical: 652-672
Cytoplasmic: 673-757