SEMA6A

The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).

Full Name

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

Function

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
(Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.

Biological Process

Biological Process animal organ morphogenesis1 PublicationNAS:UniProtKB
Biological Process apoptotic process1 PublicationNAS:UniProtKB
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell surface receptor signaling pathway1 PublicationNAS:UniProtKB
Biological Process cellular response to vascular endothelial growth factor stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process cytoskeleton organization1 PublicationNAS:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell adhesion involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process negative regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of vascular endothelial growth factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process nervous system development1 PublicationNAS:UniProtKB
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 19-649
Helical: 650-670
Cytoplasmic: 671-1030