SERPINB3
SERPINB3 (Serpin Family B Member 3) is a Protein Coding gene. Diseases associated with SERPINB3 include Anus Cancer and Cervical Squamous Cell Carcinoma. Among its related pathways are Innate Immune System and Amoebiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB4.
Full Name
Serpin Family B Member 3
Function
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH2-terminal kinase (JNK1).
Biological Process
Biological Process autocrine signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of catalytic activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of JUN kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process paracrine signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of catalytic activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of JUN kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process paracrine signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Seems to also be secreted in plasma by cancerous cells but at a low level.
Seems to also be secreted in plasma by cancerous cells but at a low level.
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Anti-SERPINB3 antibodies
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CompareTarget: SERPINB3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F5
Application*: WB, E
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA25
Application*: WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA24
Application*: WB
Target: SERPINB3
Specificity: Human
Target: SERPINB3
Specificity: Human
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2921
Application*: E, IP, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1964
Application*: WB, IH
Target: SERPINB3
Host: Mouse
Specificity: Human
Clone: CBXS-0237
Application*: WB, IC, P, C, E
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4915
Application*: IF, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4877
Application*: WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog
Clone: CBXS-4799
Application*: WB, IH, P
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4646
Application*: E, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4416
Application*: WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4174
Application*: P, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4147
Application*: P, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4093
Application*: E, P, WB
Target: SERPINB3
Host: Mouse
Specificity: Human
Clone: CBXS-3936
Application*: E, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3899
Application*: P, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3817
Application*: P, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3800
Application*: WB, IH
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3793
Application*: WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-5857
Application*: WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5743
Application*: E, WB
Target: SERPINB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5626
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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