SEZ6L2

This gene encodes a seizure-related protein that is localized on the cell surface. The gene is located in a region of chromosome 16p11.2 that is thought to contain candidate genes for autism spectrum disorders (ASD), though there is no evidence directly implicating this gene in ASD. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer. Alternative splicing of this gene results in multiple transcript variants.
Full Name
seizure related 6 homolog like 2
Function
May contribute to specialized endoplasmic reticulum functions in neurons.
Biological Process
Biological Process regulation of protein kinase C signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse maturationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
Detected on cell surface of lung-cancer.
Topology
Extracellular: 28-844
Helical: 845-865
Cytoplasmic: 866-910
PTM
O-glycosylated with core 1 or possibly core 8 glycans.
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Anti-SEZ6L2 antibodies

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Rat Anti-SEZ6L2 Recombinant Antibody (RM0530-6O34) (CBMAB-0822CQ)

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Target: SEZ6L2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0530-6O34
Application*: WB
Datasheet SDS

Rat Anti-SEZ6L2 Recombinant Antibody (CBXS-1850) (CBMAB-S4653-CQ)

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Target: SEZ6L2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1850
Application*: WB, IH
Datasheet SDS

Rat Anti-SEZ6L2 Recombinant Antibody (CBYC-P834) (CBMAB-P3663-YC)

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Target: SEZ6L2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYC-P834
Application*: IH, WB
Datasheet SDS

Human Recombinant SEZ6L2 protein, His Tag-1 (V2LY-0526-LY6743)

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Target: SEZ6L2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-736
Tag: His Tag
Datasheet SDS

Human Recombinant SEZ6L2 protein, His Tag (V2LY-0526-LY6742)

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Target: SEZ6L2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-736
Tag: His Tag
In Vivo Assay
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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