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SF3A3

This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.

Full Name

Splicing Factor 3a Subunit 3

Function

Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:8022796, PubMed:10882114, PubMed:11533230).
Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277).

Biological Process

Biological Process mRNA 3'-splice site recognitionManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process mRNA processingManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process U2-type prespliceosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus speckle
Nucleus

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Anti-SF3A3 antibodies

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Mouse Anti-SF3A3 Recombinant Antibody (CBXS-2901) (CBMAB-S5650-CQ)

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Target: SF3A3

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: CBXS-2901

Application*: E, WB

Mouse Anti-SF3A3 Recombinant Antibody (CBXS-2286) (CBMAB-S5048-CQ)

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Target: SF3A3

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-2286

Application*: WB, IP, IF, E

Rabbit Anti-SF3A3 Recombinant Antibody (CBXS-1242) (CBMAB-S4101-CQ)

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Target: SF3A3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1242

Application*: WB, F

Rabbit Anti-SF3A3 Recombinant Antibody (CBXS-1241) (CBMAB-S4100-CQ)

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Target: SF3A3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1241

Application*: WB, P, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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