SFRP5

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.

Full Name

Secreted Frizzled Related Protein 5

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Biological Process

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of Wnt signaling pathway1 PublicationNAS:ParkinsonsUK-UCL
Biological Process negative regulation of Wnt signaling pathway involved in digestive tract morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of BMP signaling pathwayIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted