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SIGLECF

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).

Full Name

sialic acid binding Ig-like lectin F

Cellular Location

Integral component of membrane

Topology

Helical: 350-375

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Anti-SIGLECF antibodies

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Rat Anti-SIGLECF Recombinant Antibody (CBXS-2581) (CBMAB-S5337-CQ)

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Target: SIGLECF

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-2581

Application*: N, WB

Rat Anti-SIGLECF Recombinant Antibody (CBXS-1717) (CBMAB-S4551-CQ)

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Target: SIGLECF

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-1717

Application*: N

Rat Anti-SIGLECF Recombinant Antibody (CBXS-1716) (CBMAB-S4550-CQ)

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Target: SIGLECF

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXS-1716

Application*: WB

Rat Anti-SIGLECF Recombinant Antibody (ES22-10D8) (CBMAB-S0442-CQ)

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Target: SIGLECF

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: ES22-10D8

Application*: F

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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