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SMPD2

This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase.
Full Name
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Function
Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884).
Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884).
Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383).
Biological Process
Biological Process ceramide biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingolipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingomyelin catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sphingomyelin metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
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Anti-SMPD2 antibodies

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Mouse Anti-SMPD2 Recombinant Antibody (4A10) (CBMAB-A8387-LY)

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Target: SMPD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4A10
Application*: E, E
Datasheet SDS

Mouse Anti-SMPD2 (AA 1-424) Recombinant Antibody (CBXS-0573) (CBMAB-S3515-CQ)

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Target: SMPD2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXS-0573
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SMPD2 Recombinant Antibody (CBXS-4465) (CBMAB-S1707-CQ)

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Target: SMPD2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-4465
Application*: E, P, WB
Datasheet SDS

Rabbit Anti-SMPD2 Recombinant Antibody (CBWJN-1680) (CBMAB-N4306-WJ)

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Target: SMPD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1680
Application*: WB, IP, IC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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