SMPD2

This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase.

Full Name

sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)

Function

Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884).
Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884).
Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383).

Biological Process

Biological Process ceramide biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingolipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingomyelin catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sphingomyelin metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Anti-SMPD2 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SMPD2 Recombinant Antibody (4A10) (CBMAB-A8387-LY)

Datasheet

SDS

Target: SMPD2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4A10

Application*: E, E

Mouse Anti-SMPD2 (AA 1-424) Recombinant Antibody (CBXS-0573) (CBMAB-S3515-CQ)

Datasheet

SDS

Target: SMPD2

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: CBXS-0573

Application*: E, IH, WB

Mouse Anti-SMPD2 Recombinant Antibody (CBXS-4465) (CBMAB-S1707-CQ)

Datasheet

SDS

Target: SMPD2

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBXS-4465

Application*: E, P, WB

Rabbit Anti-SMPD2 Recombinant Antibody (CBWJN-1680) (CBMAB-N4306-WJ)

Datasheet

SDS

Target: SMPD2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJN-1680

Application*: WB, IP, IC

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)