SULT1C2
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq]
Full Name
sulfotransferase family, cytosolic, 1C, member 4
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonates p-nitrophenol, a small phenolic compond. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:9852044, PubMed:10783263, PubMed:10481272).
Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044).
Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044).
Biological Process
Biological Process amine metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sulfationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sulfationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Lysosome
Lysosome
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Anti-SULT1C2 antibodies
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Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2141
Application*: WB, IH
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2140
Application*: WB, F, IH, P
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G1
Application*: WB, F, IH, P
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-3204
Application*: E, WB
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5192
Application*: WB
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4592
Application*: F, WB
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5913
Application*: F, P, WB
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5826
Application*: F, WB
Target: SULT1C2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5725
Application*: F, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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