TAS2R10

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq]

Full Name

taste receptor, type 2, member 10

Function

Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Biological Process

Detection of chemical stimulus involved in sensory perception of bitter taste

Cellular Location

Membrane

Topology

Extracellular: 1-6
Helical: 7-27
Cytoplasmic: 28-42
Helical: 43-63
Extracellular: 64-100
Helical: 101-121
Cytoplasmic: 122-126
Helical: 127-147
Extracellular: 148-179
Helical: 180-200
Cytoplasmic: 201-227
Helical: 228-248
Extracellular: 249-257
Helical: 258-278
Cytoplasmic: 279-307