TIAM1

TIAM1 is a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. TIAM1 thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, TIAM1 activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. TIAM1 is multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain.

T Cell Lymphoma Invasion And Metastasis 1

Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.

Biological Process activation of GTPase activitySource:ParkinsonsUK-UCL1 Publication
Biological Process cell migrationSource:UniProtKB1 Publication
Biological Process cell-matrix adhesionSource:UniProtKB1 Publication
Biological Process ephrin receptor signaling pathwaySource:Reactome
Biological Process positive regulation of axonogenesisSource:GO_Central1 Publication
Biological Process positive regulation of cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:BHF-UCL1 Publication
Biological Process positive regulation of epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process positive regulation of protein bindingSource:ParkinsonsUK-UCL1 Publication
Biological Process protein-containing complex assemblySource:ParkinsonsUK-UCL1 Publication
Biological Process Rac protein signal transductionSource:UniProtKB1 Publication
Biological Process regulation of dopaminergic neuron differentiationSource:ParkinsonsUK-UCL
Biological Process regulation of epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process regulation of non-canonical Wnt signaling pathwaySource:ParkinsonsUK-UCL
Biological Process regulation of small GTPase mediated signal transductionSource:Reactome
Biological Process small GTPase mediated signal transductionSource:GO_Central1 Publication
Biological Process Wnt signaling pathway, planar cell polarity pathwaySource:ParkinsonsUK-UCL1 Publication

Cell junction
Cell membrane
Detected at the boundary between cells with actin-rich protrusions (By similarity).
Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.

Ubiquitinated. Undergoes 'Lys-48' ubiquitination at Lys-1404 and Lys-1420 by a CUL3(KBTBD6/7) E3 ubiquitin ligase complex composed of CUL3, RBX1, KBTBD6 and KBTBD7. 'Lys-48' ubiquitination at Lys-1404 and Lys-1420 triggers proteasomal degradation (PubMed:25684205).
Ubiquitination at Lys-1404 and Lys-1420 by CUL3(KBTBD6/7) also requires the membrane-associated protein GABARAP and may therefore be spatially restricted within the cell (PubMed:25684205).