WFIKKN1
This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.
Full Name
WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 1
Function
Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).
Biological Process
Biological Process muscle cell development Source:Ensembl
Biological Process negative regulation of DNA binding Source:Ensembl
Biological Process negative regulation of protein binding Source:Ensembl
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication
Biological Process roof of mouth development Source:Ensembl
Biological Process skeletal system development Source:Ensembl
Biological Process negative regulation of DNA binding Source:Ensembl
Biological Process negative regulation of protein binding Source:Ensembl
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication
Biological Process roof of mouth development Source:Ensembl
Biological Process skeletal system development Source:Ensembl
Cellular Location
Secreted
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Anti-WFIKKN1 antibodies
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Target: WFIKKN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 289802
Application*: IH, IP, WB
Target: WFIKKN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 289827
Application*: EC
Target: WFIKKN1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJW-230
Application*: WB
Target: WFIKKN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJW-034
Application*: E, IH, IP, WB
Target: WFIKKN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2840
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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