XPO1

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

Full Name

exportin 1

Function

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.
(Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Biological Process

Biological Process mRNA transport Source:UniProtKB-KW
Biological Process nucleocytoplasmic transport Source:UniProtKB1 Publication
Biological Process protein export from nucleus Source:UniProtKB1 Publication
Biological Process protein localization to nucleus Source:Ensembl
Biological Process regulation of centrosome duplication Source:Ensembl
Biological Process regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process regulation of protein export from nucleus Source:Ensembl
Biological Process ribosomal large subunit export from nucleus Source:ParkinsonsUK-UCL1 Publication
Biological Process ribosomal small subunit export from nucleus Source:ParkinsonsUK-UCL1 Publication
Biological Process ribosomal subunit export from nucleus Source:ParkinsonsUK-UCL1 Publication
Biological Process ribosome biogenesis Source:ParkinsonsUK-UCL1 Publication

Cellular Location

Cytoplasm
Nucleus, nucleoplasm
Nucleus, Cajal body
Nucleus, nucleolus
Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.