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YES1

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Full Name
YES Proto-Oncogene 1, Src Family Tyrosine Kinase
Function
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
Biological Process
Biological Process cell differentiation Source:GO_Central1 Publication
Biological Process cellular response to platelet-derived growth factor stimulus Source:Ensembl
Biological Process cellular response to retinoic acid Source:Ensembl
Biological Process cellular response to transforming growth factor beta stimulus Source:Ensembl
Biological Process ephrin receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process leukocyte migration Source:Reactome
Biological Process negative regulation of inflammatory response to antigenic stimulus Source:Reactome
Biological Process positive regulation of peptidyl-tyrosine phosphorylation Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process regulation of glucose transmembrane transport Source:Ensembl
Biological Process regulation of vascular permeability Source:BHF-UCL1 Publication
Biological Process T cell costimulation Source:Reactome
Biological Process transmembrane receptor protein tyrosine kinase signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytosol
Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
PTM
Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.
Palmitoylation at Cys-3 promotes membrane localization.

Anti-YES1 antibodies

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Target: YES1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1747
Application*: WB, IP, IF, E
Target: YES1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYCV-149
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCV-148
Application*: E, WB, RNAi
Target: YES1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY2-114
Application*: IP, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: M250
Application*: E, WB
Target: YES1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR3173
Application*: IC/IF
Target: YES1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D846
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3C6
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 339827
Application*: WB, IH
Target: YES1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F4
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F3E6
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D5
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B8
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A12
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16C219
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B807
Application*: E, WB
Target: YES1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Dog, Mouse, Rat
Clone: CBLY2-113
Application*: WB, IF, IH
Target: YES1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D9P3E
Application*: WB, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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