ZKSCAN3

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
Full Name
ZKSCAN3
Function
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
Biological Process
Biological Process autophagy Source:UniProtKB-KW
Biological Process lysosome organization Source:UniProtKB1 Publication
Biological Process negative regulation of autophagy Source:UniProtKB1 Publication
Biological Process negative regulation of cellular senescence Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.
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Anti-ZKSCAN3 antibodies

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Mouse Anti-ZKSCAN3 Monoclonal Antibody (2E1) (CBMAB-0405-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2E1
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZKSCAN3 Monoclonal Antibody (2A9) (CBMAB-0404-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A9
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZKSCAN3 Monoclonal Antibody (2A4) (CBMAB-0403-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A4
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZKSCAN3 Monoclonal Antibody (1F9) (CBMAB-0402-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1F9
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZKSCAN3 Monoclonal Antibody (1F4) (CBMAB-0401-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1F4
Application*: IP, M
Datasheet SDS

Mouse Anti-ZKSCAN3 Monoclonal Antibody (1E8) (CBMAB-0400-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E8
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZKSCAN3 Monoclonal Antibody (1E12) (CBMAB-0399-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E12
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-ZKSCAN3 Monoclonal Antibody (1D9) (CBMAB-0398-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D9
Application*: IP, M
Datasheet SDS

Mouse Anti-ZKSCAN3 Recombinant Antibody (2A1) (CBMAB-A10164-LY)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A1
Application*: WB, E
Datasheet SDS

Mouse Anti-ZKSCAN3 Recombinant Antibody (2A1) (CBMAB-Z0493-WJ)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A1
Application*: E, WB
Datasheet SDS

Mouse Anti-ZKSCAN3 Recombinant Antibody (2A5) (CBMAB-Z0298-WJ)

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Target: ZKSCAN3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A5
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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