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ZNF346

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Full Name

Zinc Finger Protein 346

Function

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053).
May bind to specific miRNA hairpins (PubMed:28431233).

Cellular Location

Nucleus, nucleolus
Cytoplasm
Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.

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Anti-ZNF346 antibodies

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ZNF346 Matched Antibody Pair (1327) (APMAB-1327LY)

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Target: ZNF346

Specificity: Human

Mouse Anti-ZNF346 Recombinant Antibody (CBWJZ-194) (CBMAB-Z0511-WJ)

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Target: ZNF346

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJZ-194

Application*: WB

Mouse Anti-ZNF346 Recombinant Antibody (CBWJZ-128) (CBMAB-Z0510-WJ)

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Target: ZNF346

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJZ-128

Application*: WB, SE, RNAi, E

Mouse anti-ZNF346 Recombinant Antibody (2D10) (CBMAB-1319-LY)

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Target: ZNF346

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D10

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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