ZNF346

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Full Name
Zinc Finger Protein 346
Function
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053).
May bind to specific miRNA hairpins (PubMed:28431233).
Cellular Location
Nucleus, nucleolus
Cytoplasm
Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
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Anti-ZNF346 antibodies

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ZNF346 Matched Antibody Pair (1327) (APMAB-1327LY)

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Target: ZNF346
Specificity: Human
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Mouse Anti-ZNF346 Recombinant Antibody (CBWJZ-194) (CBMAB-Z0511-WJ)

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Target: ZNF346
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJZ-194
Application*: WB
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Mouse Anti-ZNF346 Recombinant Antibody (CBWJZ-128) (CBMAB-Z0510-WJ)

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Target: ZNF346
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJZ-128
Application*: WB, SE, RNAi, E
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Mouse anti-ZNF346 Recombinant Antibody (2D10) (CBMAB-1319-LY)

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Target: ZNF346
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D10
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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