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Mouse Anti-8-oxoguanine Recombinant Antibody (V2-7697) (CBMAB-1869CQ)

This product is a mouse monoclonal antibody that recognizes 8-oxoguanine. The antibody 2Q2311 can be used for immunoassay techniques such as: ELISA, ICC.
See all 8-oxoguanine antibodies
Published Data
Mouse Anti-8-oxoguanine Recombinant Antibody (2Q2311) in IF
Microglia in control and KU-60019-treated cultures were stained with 8-oxoguanine (left). The histogram represents the quantification of total fluorescent intensity of cells shown in the left panel. Error bars indicate SEM; ****p < 0.0001, by unpaired t test. ...View More
Song, X., Aw, J. T., Ma, F., Cheung, M. F., Leung, D., & Herrup, K. (2021). DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response. Journal of Neuroscience, 41(45), 9286-9307.
Mouse Anti-8-oxoguanine Recombinant Antibody (2Q2311) in IHC
Representative IHC staining of cleaved caspase-3 and 8-oxoguanine in control (upper panel), CAP (middle panel) and gemcitabine (bottom panel) treated xenograft tumors. Magnification, ×250. Scale: 200 μm. ...View More
Vaquero, J., Judée, F., Vallette, M., Decauchy, H., Arbelaiz, A., Aoudjehane, L., ... & Fouassier, L. (2020). Cold-atmospheric plasma induces tumor cell death in preclinical in vivo and in vitro models of human cholangiocarcinoma. Cancers, 12(5), 1280.
Mouse Anti-8-oxoguanine Recombinant Antibody (2Q2311) in IHC
Quantification of lung DNA oxidation by determination of the percentage of 8-oxoguanine-positive cells in the different mouse groups. Representative micrographs are shown on the right. Stained cells are indicated by red arrows. Results are individual values and means. ...View More
Breau, M., Houssaini, A., Lipskaia, L., Abid, S., Born, E., Marcos, E., ... & Adnot, S. (2019). The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice. JCI insight, 4(19).

Summary

Host Animal
Mouse
Specificity
Chemical
Clone
V2-7697
Antibody Isotype
IgM
Application
ELISA, ICC

Basic Information

Immunogen
8-oxoguanine adsorbed onto alumina
Host Species
Mouse
Specificity
Chemical
Antibody Isotype
IgM
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:50
IHC1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
8-oxoguanine
Introduction
Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.
Alternative Names
8-Oxoguanine; 8-hydroxyguanine; 8-oxo-Gua; OH8Gua
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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