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Mouse Anti-ACKR4 Recombinant Antibody (V2-261886) (CBMAB-C7935-LY)

This product is antibody recognizes CCR11. The antibody 674144 immunoassay techniques such as: FC, CyTOF.
See all ACKR4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-261886
Antibody Isotype
IgM
Application
IHC-F

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human CCR11.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Atypical Chemokine Receptor 4
Entrez Gene ID
51554
UniProt ID
Q9NPB9
Function
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
Biological Process
Calcium-mediated signaling
Cell chemotaxis
Chemotaxis
G protein-coupled receptor signaling pathway
Immune response
Positive regulation of cytosolic calcium ion concentration
Cellular Location
Early endosome; Recycling endosome; Cell membrane. Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Topology
Extracellular: 1-42 aa
Helical: 43-63 aa
Cytoplasmic: 64-87 aa
Helical: 88-108 aa
Extracellular: 109-113 aa
Helical: 114-134 aa
Cytoplasmic: 135-154 aa
Helical: 155-175 aa
Extracellular: 176-201 aa
Helical: 202-222 aa
Cytoplasmic: 223-240 aa
Helical: 241-261 aa
Extracellular: 262-289 aa
Helical: 290-310 aa
Cytoplasmic: 311-350 aa
PTM
The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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