ACKR4

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

Full Name

Atypical Chemokine Receptor 4

Function

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding leads to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

Biological Process

Calcium-mediated signaling
Cell chemotaxis
Chemotaxis
G protein-coupled receptor signaling pathway
Immune response
Positive regulation of cytosolic calcium ion concentration

Cellular Location

Early endosome; Recycling endosome; Cell membrane. Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Topology

Extracellular: 1-42 aa
Helical: 43-63 aa
Cytoplasmic: 64-87 aa
Helical: 88-108 aa
Extracellular: 109-113 aa
Helical: 114-134 aa
Cytoplasmic: 135-154 aa
Helical: 155-175 aa
Extracellular: 176-201 aa
Helical: 202-222 aa
Cytoplasmic: 223-240 aa
Helical: 241-261 aa
Extracellular: 262-289 aa
Helical: 290-310 aa
Cytoplasmic: 311-350 aa

PTM

The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.