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Mouse Anti-AIFM2 Recombinant Antibody (V2-180347) (CBMAB-A1807-YC)

Provided herein is a Mouse monoclonal antibody against Human Apoptosis Inducing Factor, Mitochondria Associated 2. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all AIFM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180347
Antibody Isotype
IgG1, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 1-339 from human AMID (AAH06121) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Apoptosis Inducing Factor, Mitochondria Associated 2
Introduction
AIFM2 is a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon ca
Entrez Gene ID
84883
UniProt ID
Q9BRQ8
Alternative Names
Apoptosis Inducing Factor, Mitochondria Associated 2; Apoptosis-Inducing Factor (AIF)-Like Mitochondrion-Associated Inducer Of Death; Apoptosis-Inducing Factor, Mitochondrion-Associated, 2; P53-Responsive Gene 3 Protein; AMID; PRG3;
Function
A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels (PubMed:31634899, PubMed:31634900). May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472). Capable of DNA binding in a non-sequence specific way (PubMed:15958387).
Biological Process
Apoptotic mitochondrial changes Source: MGI
Negative regulation of ferroptosis Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Regulation of apoptotic process Source: Reactome
Regulation of cellular response to oxidative stress Source: UniProtKB
Ubiquinone metabolic process Source: UniProtKB
Cellular Location
Cytoplasm; Cell membrane; Nucleus; Mitochondrion membrane; Lipid droplet
Topology
Helical: 7-27 aa
PTM
N-myristoylation at Gly-2 mediates the recruitment to lipid droplets and plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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