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Mouse Anti-AIPL1 Recombinant Antibody (V2-180366) (CBMAB-A1835-YC)

Provided herein is a Mouse monoclonal antibody against Human Aryl Hydrocarbon Receptor Interacting Protein Like 1. The antibody can be used for immunoassay techniques, such as FC, IF, IHC, WB.
See all AIPL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180366
Antibody Isotype
IgG1
Application
IHC-F, IF, IHC, WB

Basic Information

Immunogen
Full length recombinant protein of human AIPL1 (NP_055151) produced in HEK293T cell.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IHC1:150
IF(ICC)1:100
FC1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aryl Hydrocarbon Receptor Interacting Protein Like 1
Introduction
Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with ny
Entrez Gene ID
23746
UniProt ID
Q9NZN9
Alternative Names
Aryl Hydrocarbon Receptor Interacting Protein Like 1; AIPL2; Aryl Hydrocarbon Receptor-Interacting Protein-Like 1; Aryl Hydrocarbon Receptor Interacting Protein-Like 1; Aryl-Hydrocarbon-Interacting Protein-Like 1; LCA4;
Function
May be important in protein trafficking and/or protein folding and stabilization.
Biological Process
Negative regulation of apoptotic process Source: Ensembl
Phototransduction, visible light Source: Ensembl
Protein farnesylation Source: MGI
Regulation of rhodopsin mediated signaling pathway Source: Ensembl
Retina homeostasis Source: Ensembl
Visual perception Source: ProtInc
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Leber congenital amaurosis 4 (LCA4): A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.

Lukovic, D., Castro, A. A., Kaya, K. D., Munezero, D., Gieser, L., Davó-Martínez, C., ... & Erceg, S. (2020). Retinal Organoids derived from hiPSCs of an AIPL1-LCA Patient Maintain Cytoarchitecture despite Reduced levels of Mutant AIPL1. Scientific reports, 10(1), 1-13.

Yadav, R. P., Boyd, K., Yu, L., & Artemyev, N. O. (2019). Interaction of the TPR-domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory P [gamma] subunit of phosphodiesterase 6. J. Biol. Chem., 294(43); 10, 2019).

Yadav, R. P., Boyd, K., Yu, L., & Artemyev, N. O. (2019). Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor–interacting protein–like 1 with the regulatory Pγ subunit of phosphodiesterase 6. Journal of Biological Chemistry, 294(43), 15795-15807.

Yu, L., Yadav, R. P., & Artemyev, N. O. (2019). NMR resonance assignments of the TPR domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1). Biomolecular NMR assignments, 13(1), 79-83.

Sacristan-Reviriego, A., & van der Spuy, J. (2018). The leber congenital amaurosis-linked protein AIPL1 and its critical role in photoreceptors. Retinal Degenerative Diseases, 381-386.

Lukovic, D., Castro, A. A., León, M., del Buey Furió, V., Cortón, M., Ayuso, C., & Erceg, S. (2018). Generation of a human iPSC line from a patient with Leber congenital amaurosis caused by mutation in AIPL1. Stem cell research, 33, 151-155.

Yu, L., Yadav, R. P., & Artemyev, N. O. (2017). NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand. Biomolecular NMR assignments, 11(1), 111-115.

Yadav, R. P., & Artemyev, N. O. (2017). AIPL1: A specialized chaperone for the phototransduction effector. Cellular signalling, 40, 183-189.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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