Mouse Anti-AIPL1 Recombinant Antibody (V2-180365) (CBMAB-A1834-YC)

Name: Mouse Anti-AIPL1 Recombinant Antibody (V2-180365)
SKU: CBMAB-A1834-YC
Rating: 5 (1 reviews)

See all AIPL1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-180365

Application

ELISA, IP

Immunogen

AIPL1 (NP_055151. 3, 1-101 aa) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-101

More Infomation

Target

Full Name

Aryl Hydrocarbon Receptor Interacting Protein Like 1

Introduction

Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with ny

Entrez Gene ID

23746

UniProt ID

Q9NZN9

Alternative Names

Aryl Hydrocarbon Receptor Interacting Protein Like 1; AIPL2; Aryl Hydrocarbon Receptor-Interacting Protein-Like 1; Aryl Hydrocarbon Receptor Interacting Protein-Like 1; Aryl-Hydrocarbon-Interacting Protein-Like 1; LCA4;

Function

May be important in protein trafficking and/or protein folding and stabilization.

Biological Process

Negative regulation of apoptotic process Source: Ensembl
Phototransduction, visible light Source: Ensembl
Protein farnesylation Source: MGI
Regulation of rhodopsin mediated signaling pathway Source: Ensembl
Retina homeostasis Source: Ensembl
Visual perception Source: ProtInc

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Leber congenital amaurosis 4 (LCA4): A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.

Lukovic, D., Castro, A. A., Kaya, K. D., Munezero, D., Gieser, L., Davó-Martínez, C., ... & Erceg, S. (2020). Retinal Organoids derived from hiPSCs of an AIPL1-LCA Patient Maintain Cytoarchitecture despite Reduced levels of Mutant AIPL1. Scientific reports, 10(1), 1-13.

Yadav, R. P., Boyd, K., Yu, L., & Artemyev, N. O. (2019). Interaction of the TPR-domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory P [gamma] subunit of phosphodiesterase 6. J. Biol. Chem., 294(43); 10, 2019).

Yadav, R. P., Boyd, K., Yu, L., & Artemyev, N. O. (2019). Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor–interacting protein–like 1 with the regulatory Pγ subunit of phosphodiesterase 6. Journal of Biological Chemistry, 294(43), 15795-15807.

Yu, L., Yadav, R. P., & Artemyev, N. O. (2019). NMR resonance assignments of the TPR domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1). Biomolecular NMR assignments, 13(1), 79-83.

Sacristan-Reviriego, A., & van der Spuy, J. (2018). The leber congenital amaurosis-linked protein AIPL1 and its critical role in photoreceptors. Retinal Degenerative Diseases, 381-386.

Lukovic, D., Castro, A. A., León, M., del Buey Furió, V., Cortón, M., Ayuso, C., & Erceg, S. (2018). Generation of a human iPSC line from a patient with Leber congenital amaurosis caused by mutation in AIPL1. Stem cell research, 33, 151-155.

Yu, L., Yadav, R. P., & Artemyev, N. O. (2017). NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand. Biomolecular NMR assignments, 11(1), 111-115.

Yadav, R. P., & Artemyev, N. O. (2017). AIPL1: A specialized chaperone for the phototransduction effector. Cellular signalling, 40, 183-189.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-AIPL1 Recombinant Antibody (V2-180365)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

AIPL1 Matched Antibody Pair (042) (CAT#: APMAB-042LY)

AIPL1 Matched Antibody Pair (043) (CAT#: APMAB-043LY)

Related Products

Mouse Anti-AIPL1 Recombinant Antibody (V2-180362) (CAT#: CBMAB-A1831-YC)

AIPL1 Matched Antibody Pair (042) (CAT#: APMAB-042LY)

Mouse Anti-AIPL1 Recombinant Antibody (V2-180363) (CAT#: CBMAB-A1832-YC)

Mouse Anti-AIPL1 Recombinant Antibody (V2-180364) (CAT#: CBMAB-A1833-YC)

Mouse Anti-AIPL1 Recombinant Antibody (V2-180361) (CAT#: CBMAB-A1830-YC)

Mouse Anti-AIPL1 Recombinant Antibody (V2-180366) (CAT#: CBMAB-A1835-YC)

AIPL1 Matched Antibody Pair (043) (CAT#: APMAB-043LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry