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Rat Anti-BMF Recombinant Antibody (CBYY-1880) (CBMAB-2229-YY)

This product is rat antibody that recognizes BMF. The antibody CBYY-1880 can be used for immunoassay techniques such as: ELISA, FC, ICC, IHC, IP, WB
See all BMF antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-1880
Antibody Isotype
IgG2a, κ
Application
ELISA, FC, ICC, IHC, IP, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bcl2 Modifying Factor
Introduction
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforMouse have been identified.
Entrez Gene ID
171543
UniProt ID
A2AV74
Alternative Names
Bcl2 Modifying Factor;
Function
May play a role in apoptosis. Isoform 1 seems to be the main initiator.
Biological Process
Anoikis Source: MGI
Cellular response to UV Source: CAFA
Negative regulation of autophagy Source: CAFA
Positive regulation of apoptotic process Source: BHF-UCL
Positive regulation of intrinsic apoptotic signaling pathway Source: Reactome
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Cellular Location
Myosin complex; Cytosol; Mitochondrial outer membrane; Plasma membrane; Acrosomal vesicle

Vaz, S., Ferreira, F. J., Macedo, J. C., Leor, G., Ben-David, U., Bessa, J., & Logarinho, E. (2021). FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell death & disease, 12(6), 1-14.

Badr, E. A., Assar, M. F., Eltorgoman, A. M. A., Labeeb, A. Z., Breaka, G. A., & Elkhouly, E. A. (2020). A correlation between BCL-2 modifying factor, p53 and livin gene expressions in cancer colon patients. Biochemistry and biophysics reports, 22, 100747.

Lin, X., Zhan, J. K., Zhong, J. Y., Wang, Y. J., Wang, Y., Li, S., ... & Liu, Y. S. (2019). lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs. Aging (Albany NY), 11(2), 523.

Sul, O. J., Rajasekaran, M., Park, H. J., Suh, J. H., & Choi, H. S. (2019). MicroRNA-29b enhances osteoclast survival by targeting BCL-2-modifying factor after lipopolysaccharide stimulation. Oxidative medicine and cellular longevity, 2019.

Ghosh, A., Zhao, S., Lo, C. S., Maachi, H., Chenier, I., Lateef, M. A., ... & Chan, J. S. (2019). Heterogeneous nuclear ribonucleoprotein F mediates insulin inhibition of Bcl2-modifying factor expression and tubulopathy in diabetic kidney. Scientific reports, 9(1), 1-16.

Fan, Y. X., Bian, X. H., Qian, P. D., Chen, Z. Z., Wen, J., Luo, Y. H., ... & Zhang, Q. (2018). MicroRNA-125b inhibits cell proliferation and induces cell apoptosis in esophageal squamous cell carcinoma by targeting BMF. Oncology reports, 40(1), 61-72.

Guo, X., Xiang, C., Zhang, Z., Zhang, F., Xi, T., & Zheng, L. (2018). Displacement of Bax by BMF mediates STARD13 3′ UTR-induced breast cancer cells apoptosis in an miRNA-depedent manner. Molecular pharmaceutics, 15(1), 63-71.

Akhter, R., Saleem, S., Saha, A., & Biswas, S. C. (2018). The pro-apoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by β-amyloid or NGF deprivation. Molecular and Cellular Neuroscience, 88, 249-257.

Liew, S. H., Nguyen, Q. N., Strasser, A., Findlay, J. K., & Hutt, K. J. (2017). The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF. Cell death & disease, 8(8), e2971-e2971.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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