BMF

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.

Bcl2 Modifying Factor

May play a role in apoptosis. Isoform 1 seems to be the main initiator.

Anoikis Source: MGI
Cellular response to UV Source: CAFA
Negative regulation of autophagy Source: CAFA
Positive regulation of apoptotic process Source: BHF-UCL
Positive regulation of intrinsic apoptotic signaling pathway Source: Reactome
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome

Myosin complex; Cytosol; Mitochondrial outer membrane; Plasma membrane; Acrosomal vesicle