Human Recombinant BMF protein, His Tag (V2LY-0526-LY2366)

Go to compare Compare Online Inquiry
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host
E. coli
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant BMF protein, His Tag consist of Amino Acid: 1-184 and predicts a molecular mass of 22.3 kDa.
Molecule Mass
22.3 kDa
Sequence
Amino Acid: 1-184
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>85% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Bcl2 Modifying Factor
Function
May play a role in apoptosis. Isoform 1 seems to be the main initiator.
Biological Process
Anoikis Source: MGI
Cellular response to UV Source: CAFA
Negative regulation of autophagy Source: CAFA
Positive regulation of apoptotic process Source: BHF-UCL
Positive regulation of intrinsic apoptotic signaling pathway Source: Reactome
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Cellular Location
Myosin complex; Cytosol; Mitochondrial outer membrane; Plasma membrane; Acrosomal vesicle

Vaz, S., Ferreira, F. J., Macedo, J. C., Leor, G., Ben-David, U., Bessa, J., & Logarinho, E. (2021). FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell death & disease, 12(6), 1-14.

Badr, E. A., Assar, M. F., Eltorgoman, A. M. A., Labeeb, A. Z., Breaka, G. A., & Elkhouly, E. A. (2020). A correlation between BCL-2 modifying factor, p53 and livin gene expressions in cancer colon patients. Biochemistry and biophysics reports, 22, 100747.

Lin, X., Zhan, J. K., Zhong, J. Y., Wang, Y. J., Wang, Y., Li, S., ... & Liu, Y. S. (2019). lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs. Aging (Albany NY), 11(2), 523.

Sul, O. J., Rajasekaran, M., Park, H. J., Suh, J. H., & Choi, H. S. (2019). MicroRNA-29b enhances osteoclast survival by targeting BCL-2-modifying factor after lipopolysaccharide stimulation. Oxidative medicine and cellular longevity, 2019.

Ghosh, A., Zhao, S., Lo, C. S., Maachi, H., Chenier, I., Lateef, M. A., ... & Chan, J. S. (2019). Heterogeneous nuclear ribonucleoprotein F mediates insulin inhibition of Bcl2-modifying factor expression and tubulopathy in diabetic kidney. Scientific reports, 9(1), 1-16.

Fan, Y. X., Bian, X. H., Qian, P. D., Chen, Z. Z., Wen, J., Luo, Y. H., ... & Zhang, Q. (2018). MicroRNA-125b inhibits cell proliferation and induces cell apoptosis in esophageal squamous cell carcinoma by targeting BMF. Oncology reports, 40(1), 61-72.

Guo, X., Xiang, C., Zhang, Z., Zhang, F., Xi, T., & Zheng, L. (2018). Displacement of Bax by BMF mediates STARD13 3′ UTR-induced breast cancer cells apoptosis in an miRNA-depedent manner. Molecular pharmaceutics, 15(1), 63-71.

Akhter, R., Saleem, S., Saha, A., & Biswas, S. C. (2018). The pro-apoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by β-amyloid or NGF deprivation. Molecular and Cellular Neuroscience, 88, 249-257.

Liew, S. H., Nguyen, Q. N., Strasser, A., Findlay, J. K., & Hutt, K. J. (2017). The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF. Cell death & disease, 8(8), e2971-e2971.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Human Recombinant BMF protein, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.