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Rabbit Anti-BRD1 (AA 410-460) Recombinant Antibody (CBYY-0798) (CBMAB-0801-YY)

This product is rabbit antibody that recognizes BRD1. The antibody CBYY-0798 can be used for immunoassay techniques such as: WB
See all BRD1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBYY-0798
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.715 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 410-460

Target

Full Name
BRD1
Introduction
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human23774
Mouse223770
Rat315210
UniProt ID
HumanO95696
MouseG5E8P1
RatD3ZUW8
Alternative Names
Bromodomain Containing 1; Bromodomain And PHD Finger-Containing Protein 2; BR140-Like Protein; BRPF2; BRL; Bromodomain-Containing Protein 1; Bromodomain-Containing 1; BR140-Like; BRPF1;
Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189).
Biological Process
Erythrocyte maturation Source: UniProtKB-KW
Histone H3 acetylation Source: UniProtKB
Histone H3-K14 acetylation Source: UniProtKB
Histone H3-K23 acetylation Source: GOC
Positive regulation of erythrocyte differentiation Source: UniProtKB
Response to electrical stimulus Source: Ensembl
Response to immobilization stress Source: Ensembl
Cellular Location
Nucleus; Chromosome. Localizes to transcription start sites.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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