BRD1

This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants.
Full Name
BRD1
Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189).
Biological Process
Erythrocyte maturation Source: UniProtKB-KW
Histone H3 acetylation Source: UniProtKB
Histone H3-K14 acetylation Source: UniProtKB
Histone H3-K23 acetylation Source: GOC
Positive regulation of erythrocyte differentiation Source: UniProtKB
Response to electrical stimulus Source: Ensembl
Response to immobilization stress Source: Ensembl
Cellular Location
Nucleus; Chromosome. Localizes to transcription start sites.
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Anti-BRD1 antibodies

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Mouse Anti-BRD1 Recombinant Antibody (CBYY-1950) (CBMAB-2299-YY)

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Target: BRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1950
Application*: WB, IP
Datasheet SDS

Mouse Anti-BRD1 Antibody (2E4) (CBMAB-0170-YC)

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Target: BRD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2E4
Application*: E, IP
Datasheet SDS

Mouse Anti-BRD1 Antibody (12B2) (CBMAB-0169-YC)

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Target: BRD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 12B2
Application*: E
Datasheet SDS

Mouse Anti-BRD1 Antibody (1B5) (CBMAB-0168-YC)

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Target: BRD1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1B5
Application*: IP, M
Datasheet SDS

Mouse Anti-BRD1 Recombinant Antibody (CBYY-1946) (CBMAB-2295-YY)

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Target: BRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-1946
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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