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Mouse Anti-ADIPOR2 Recombinant Antibody (V2-179983) (CBMAB-A1369-YC)

Provided herein is a Mouse monoclonal antibody against Human Adiponectin Receptor 2. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ADIPOR2 antibodies
Published Data
Mouse Anti-ADIPOR2 Recombinant Antibody (A-3) (CBMAB-A1369-YC) in IHC
Representative images of immunohistochemical staining for the detection of AdipoR1 and AdipoR2 in hypertrophic scar (HS) and counterpart normal skin (NS) tissues, scale bar = 200 and 100μm. ...View More
Zhang, J., Li, Y., Liu, J., Han, F., Shi, J., Wu, G., ... & Hu, D. (2022). Adiponectin ameliorates hypertrophic scar by inhibiting Yes-associated protein transcription through SIRT1-mediated deacetylation of C/EBPβ and histone H3. Iscience, 25(10), 105236.
Mouse Anti-ADIPOR2 Recombinant Antibody (A-3) (CBMAB-A1369-YC) in WB
The protein levels of AdipoR1 and AdipoR2 from five pairs of NS and HS tissues were detected by Western blot. ...View More
Zhang, J., Li, Y., Liu, J., Han, F., Shi, J., Wu, G., ... & Hu, D. (2022). Adiponectin ameliorates hypertrophic scar by inhibiting Yes-associated protein transcription through SIRT1-mediated deacetylation of C/EBPβ and histone H3. Iscience, 25(10), 105236.
Mouse Anti-ADIPOR2 Recombinant Antibody (A-3) (CBMAB-A1369-YC) in WB
Effect of BSKS on the expression of adiponectin and its receptors as well as TLR4 and NF-κB p65 in the atherosclerotic aorta of ApoE−/− mice. The expressions of adiponectin, AdipoR1, AdipoR2, TLR4, and NF-κB p65 in the atherosclerotic aorta of ApoE−/− mice were detected by western blot. The expressions of adiponectin, AdipoR1, AdipoR2, TLR4, and NF-κB p65 were quantitatively compared between drug treatment groups and model group (n = 3). Data are shown as mean ± standard deviation and compared by one-way analysis of variance followed by Fisher's Least Significant Difference test for individual comparisons.  n.s.P> 0.05;  ⋆P < 0.05;  ⋆⋆P < 0.01. ...View More
Pang, S. C., Peng, L., Zhang, J. P., Wang, Y. Y., Jia, H. Y., Bi, L. Y., & Chen, M. L. (2018). Bushenkangshuai tablet reduces atherosclerotic lesion by improving blood lipids metabolism and inhibiting inflammatory response via TLR4 and NF-κB signaling pathway. Evidence-Based Complementary and Alternative Medicine, 2018.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-179983
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 61-89 near the N-terminus of AdipoR2 of mouse origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adiponectin Receptor 2
Introduction
The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
Entrez Gene ID
Human79602
Mouse68465
Rat312670
UniProt ID
HumanQ86V24
MouseQ8BQS5
RatQ3YAF7
Alternative Names
Adiponectin Receptor 2; Progestin And AdipoQ Receptor Family Member II; Progestin And AdipoQ Receptor Family Member 2; PAQR2; Adiponectin Receptor Protein 2; ACDCR2;
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
Biological Process
Adiponectin-activated signaling pathway
Cellular response to fatty acid
Fatty acid oxidation
Female pregnancy
Glucose homeostasis
Heart development
Hormone-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of gene expression
Negative regulation of hepatic stellate cell migration
Positive regulation of cold-induced thermogenesis
Positive regulation of glucose import
Positive regulation of protein phosphorylation
Regulation of fatty acid biosynthetic process
Response to amine
Response to drug
Response to ethanol
Response to fructose
Response to lipopolysaccharide
Response to nutrient
Vascular wound healing
Cellular Location
Cell membrane. Localized to the cell membrane and intracellular organelles.
Topology
Cytoplasmic: 1-147 aa
Helical: 148-168 aa
Extracellular: 169-181 aa
Helical: 182-202 aa
Cytoplasmic: 203-213 aa
Helical: 214-234 aa
Extracellular: 235-245 aa
Helical: 246-266 aa
Cytoplasmic: 267-273 aa
Helical: 274-294 aa
Extracellular: 295-309 aa
Helical: 310-330 aa
Cytoplasmic: 331-348 aa
Helical: 349-369 aa
Extracellular: 370-386 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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