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Mouse Anti-ADIPOR2 Recombinant Antibody (V2-356445) (CBMAB-P0029-YC)

Provided herein is a Mouse monoclonal antibody against Rat Adiponectin Receptor 2. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all ADIPOR2 antibodies
Published Data
Mouse Anti-ADIPOR2 Recombinant Antibody (CBYC-P008) (CBMAB-P0029-YC) in IHC
liver AdipoR2 protein expression (immunohistochemical staining) *400; Compared with normal rats, the expression of AdipoR2 in type 2 diabetic rats increased. 30 days after HBO, The AdipoR2 in type 2 diabetic rats is lower than that type 2 diabetic rats without HBO. It was demonstrated that HBO reduced the expression of AdipoR2 in type 2 diabetic rats.(a: Normal control group; b: Diabetes control group; c: Diabetes after HBO for 30 days group). ...View More
Liang, L., Gao, G., & Wu, J. (2018). Effects of hyperbaric oxygen on adiponect and glucose transporter 4 expression in type 2 diabetic rats. Chronic Dis Prev Rev, 6, 1-5.
Mouse Anti-ADIPOR2 Recombinant Antibody (CBYC-P008) (CBMAB-P0029-YC) in IHC
Representative immunohistochemistry of AdipoR2 in a D5 (A-C) and D7 (D-F) CL using NovaRED® (Vector Laboratories) and stained with hematoxylin. Panels A and D are 20× magnification of the tissue section. Panels B and E are 40× magnification of tissue sections A and D, respectively. Panels C and F are 40× magnification of tissue sections incubated in normal serum. Star indicates vessel, black arrow points to small luteal cells, and black arrowhead points to large luteal cells. Scale bar is 20 μm in 20× magnification panels and 50 μm in 40× magnification panels. ...View More
Flores, R., Ramirez, M., Ayala, L., Benavides, E. A., Xie, F., Arellano, A. A., ... & Garcia, M. R. (2022). Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum. Veterinary Sciences, 9(2), 77.

Summary

Host Animal
Mouse
Specificity
Rat
Clone
V2-356445
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, ELISA

Basic Information

Immunogen
Adiponectin Receptor 2
Host Species
Mouse
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:50-1:200
IHC1:50-1:200
WB1:500-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Buffer
PBS, pH7.4, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adiponectin Receptor 2
Introduction
The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
Entrez Gene ID
312670
UniProt ID
Q3YAF7
Alternative Names
Adiponectin Receptor 2; Progestin And AdipoQ Receptor Family Member II; Progestin And AdipoQ Receptor Family Member 2; PAQR2; Adiponectin Receptor Protein 2; ACDCR2;
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
Biological Process
Adiponectin-activated signaling pathway
Cellular response to fatty acid
Fatty acid oxidation
Female pregnancy
Glucose homeostasis
Heart development
Hormone-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of gene expression
Negative regulation of hepatic stellate cell migration
Positive regulation of cold-induced thermogenesis
Positive regulation of glucose import
Positive regulation of protein phosphorylation
Regulation of fatty acid biosynthetic process
Response to amine
Response to drug
Response to ethanol
Response to fructose
Response to lipopolysaccharide
Response to nutrient
Vascular wound healing
Cellular Location
Cell membrane. Localized to the cell membrane and intracellular organelles.
Topology
Cytoplasmic: 1-147 aa
Helical: 148-168 aa
Extracellular: 169-181 aa
Helical: 182-202 aa
Cytoplasmic: 203-213 aa
Helical: 214-234 aa
Extracellular: 235-245 aa
Helical: 246-266 aa
Cytoplasmic: 267-273 aa
Helical: 274-294 aa
Extracellular: 295-309 aa
Helical: 310-330 aa
Cytoplasmic: 331-348 aa
Helical: 349-369 aa
Extracellular: 370-386 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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