Mouse Anti-ADIPOR2 Recombinant Antibody (V2-356446) (CBMAB-P0030-YC)

Name: Mouse Anti-ADIPOR2 Recombinant Antibody (V2-356446)
SKU: CBMAB-P0030-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-356446

Application

WB, ICC, IHC-P, ELISA

Immunogen

Adiponectin Receptor 2

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	1:50-1:200
IHC	1:50-1:200
WB	1:500-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.4, 0.02% sodium azide, 50% glycerol

Buffer

PBS, pH7.4, 50% Glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Adiponectin Receptor 2

Introduction

The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.

Entrez Gene ID

79602

UniProt ID

Q86V24

Alternative Names

ACDCR2; PAQR2

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Biological Process

Adiponectin-activated signaling pathway
Cellular response to fatty acid
Fatty acid oxidation
Female pregnancy
Glucose homeostasis
Heart development
Hormone-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of gene expression
Negative regulation of hepatic stellate cell migration
Positive regulation of cold-induced thermogenesis
Positive regulation of glucose import
Positive regulation of protein phosphorylation
Regulation of fatty acid biosynthetic process
Response to amine
Response to drug
Response to ethanol
Response to fructose
Response to lipopolysaccharide
Response to nutrient
Vascular wound healing

Cellular Location

Cell membrane. Localized to the cell membrane and intracellular organelles.

Topology

Cytoplasmic: 1-147 aa
Helical: 148-168 aa
Extracellular: 169-181 aa
Helical: 182-202 aa
Cytoplasmic: 203-213 aa
Helical: 214-234 aa
Extracellular: 235-245 aa
Helical: 246-266 aa
Cytoplasmic: 267-273 aa
Helical: 274-294 aa
Extracellular: 295-309 aa
Helical: 310-330 aa
Cytoplasmic: 331-348 aa
Helical: 349-369 aa
Extracellular: 370-386 aa

Sircar, R., & Belbin, T. J. (2021). Adiponectin receptor2 and HCLS1 associated proteinX-1 levels are altered in postmortem schizophrenic brain. Meta Gene, 27, 100834.

Tahani, M., Goodarzi, M. T., Ahmadi, A. A., Hasani, M. H., Farrahi, A., & Selakjani, A. M. (2021). Single-Nucleotide Polymorphism of rs11061971 (+ 219 A> T) in Adiponectin Receptor 2 (AdipoR2) Gene and Its Association with Risk of Type 2 Diabetes Among an Iranian Population.

Gasbarrino, K., Zheng, H., Hafiane, A., Veinot, J. P., Lai, C., & Daskalopoulou, S. S. (2017). Decreased adiponectin-mediated signaling through the AdipoR2 pathway is associated with carotid plaque instability. Stroke, 48(4), 915-924.

Zhou, L., Zhang, H. F., Ning, W., Song, X., Liu, X., & Liu, J. X. (2017). Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study. Molecular medicine reports, 16(4), 3983-3993.

Devkota, R., Svensk, E., Ruiz, M., Ståhlman, M., Borén, J., & Pilon, M. (2017). The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids. PLoS genetics, 13(9), e1007004.

Solayman, M., Saleh, M. A., Paul, S., Khalil, M. I., & Gan, S. H. (2017). In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene. Computational biology and chemistry, 68, 175-185.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-ADIPOR2 Recombinant Antibody (V2-179983) (CAT#: CBMAB-A1369-YC)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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