ADIPOR2

The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.

Full Name

Adiponectin Receptor 2

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Biological Process

Adiponectin-activated signaling pathway
Cellular response to fatty acid
Fatty acid oxidation
Female pregnancy
Glucose homeostasis
Heart development
Hormone-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of gene expression
Negative regulation of hepatic stellate cell migration
Positive regulation of cold-induced thermogenesis
Positive regulation of glucose import
Positive regulation of protein phosphorylation
Regulation of fatty acid biosynthetic process
Response to amine
Response to drug
Response to ethanol
Response to fructose
Response to lipopolysaccharide
Response to nutrient
Vascular wound healing

Cellular Location

Cell membrane. Localized to the cell membrane and intracellular organelles.

Topology

Cytoplasmic: 1-147 aa
Helical: 148-168 aa
Extracellular: 169-181 aa
Helical: 182-202 aa
Cytoplasmic: 203-213 aa
Helical: 214-234 aa
Extracellular: 235-245 aa
Helical: 246-266 aa
Cytoplasmic: 267-273 aa
Helical: 274-294 aa
Extracellular: 295-309 aa
Helical: 310-330 aa
Cytoplasmic: 331-348 aa
Helical: 349-369 aa
Extracellular: 370-386 aa