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Mouse Anti-C3AR1 Recombinant Antibody (9L804) (CBMAB-C1158-CN)

This product is a Mouse antibody that recognizes C3AR1. The antibody 9L804 can be used for immunoassay techniques such as: ELISA, FC.
See all C3AR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9L804
Antibody Isotype
IgG2a
Application
ELISA, FC

Basic Information

Immunogen
Human C3a R transfected NS0 cells (NP_000055). Species Sequence Homology: mouse; 50%, rat; 42%
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, 5% trehalose. Reconstitute with 0.2 mL sterile PBS
Concentration
0.5 mg/mL (after reconstitution)

Target

Full Name
Complement C3a Receptor 1
Introduction
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization.
Entrez Gene ID
719
UniProt ID
Q16581
Alternative Names
AZ3B; C3AR; HNFAG09
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Biological Process
Blood circulation Source: ProtInc
Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: Ensembl
Positive regulation of neutrophil chemotaxis Source: Ensembl
Positive regulation of vascular endothelial growth factor production Source: Ensembl
Purinergic nucleotide receptor signaling pathway Source: Reactome
Regulation of complement activation Source: Reactome
Cellular Location
Cell membrane
Topology
Extracellular: 1-23 aa
Helical: 24-46 aa
Cytoplasmic: 47-57 aa
Helical: 58-80 aa
Extracellular: 81-96 aa
Helical: 97-118 aa
Cytoplasmic: 119-139 aa
Helical: 140-160 aa
Extracellular: 161-340 aa
Helical: 341-360 aa
Cytoplasmic: 361-377 aa
Helical: 378-400 aa
Extracellular: 401-417 aa
Helical: 418-438 aa
Cytoplasmic: 439-482 aa
PTM
Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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