C3AR1

C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization.

Complement C3a Receptor 1

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Blood circulation Source: ProtInc
Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: Ensembl
Positive regulation of neutrophil chemotaxis Source: Ensembl
Positive regulation of vascular endothelial growth factor production Source: Ensembl
Purinergic nucleotide receptor signaling pathway Source: Reactome
Regulation of complement activation Source: Reactome

Cell membrane

Extracellular: 1-23 aa
Helical: 24-46 aa
Cytoplasmic: 47-57 aa
Helical: 58-80 aa
Extracellular: 81-96 aa
Helical: 97-118 aa
Cytoplasmic: 119-139 aa
Helical: 140-160 aa
Extracellular: 161-340 aa
Helical: 341-360 aa
Cytoplasmic: 361-377 aa
Helical: 378-400 aa
Extracellular: 401-417 aa
Helical: 418-438 aa
Cytoplasmic: 439-482 aa

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
O-glycosylated.