C3AR1

C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization.
Full Name
Complement C3a Receptor 1
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Biological Process
Blood circulation Source: ProtInc
Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: Ensembl
Positive regulation of neutrophil chemotaxis Source: Ensembl
Positive regulation of vascular endothelial growth factor production Source: Ensembl
Purinergic nucleotide receptor signaling pathway Source: Reactome
Regulation of complement activation Source: Reactome
Cellular Location
Cell membrane
Topology
Extracellular: 1-23 aa
Helical: 24-46 aa
Cytoplasmic: 47-57 aa
Helical: 58-80 aa
Extracellular: 81-96 aa
Helical: 97-118 aa
Cytoplasmic: 119-139 aa
Helical: 140-160 aa
Extracellular: 161-340 aa
Helical: 341-360 aa
Cytoplasmic: 361-377 aa
Helical: 378-400 aa
Extracellular: 401-417 aa
Helical: 418-438 aa
Cytoplasmic: 439-482 aa
PTM
Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
O-glycosylated.
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Anti-C3AR1 antibodies

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Mouse Anti-C3AR1 Recombinant Antibody (3G7) (CBMAB-C6177-LY)

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Target: C3AR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G7
Application*: E, FC, IF
Datasheet SDS

Human C3AR1 ELISA Kit (2) (V2LY-0626-LY5536)

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Target: C3AR1
Sensitivity: 0.0098 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human C3AR1 ELISA Kit (V2LY-0626-LY5534)

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Target: C3AR1
Sensitivity: 0.0065 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-C3AR1 Recombinant Antibody (CBT4487) (V2LY-0625-LY1834)

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Target: C3AR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4487
Application*: F
Datasheet SDS

Mouse Anti-C3AR1 Recombinant Antibody (CBHb390) (CBMAB-Hb115-LY)

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Target: C3AR1
Host: Mouse
Antibody Isotype: IgG2b, ĸ
Specificity: Human
Clone: CBHb390
Application*: WB, IP, IF, FC
Datasheet SDS

Mouse Anti-C3AR1 Recombinant Antibody (CBFYA-0164) (CBMAB-X0237-FY)

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Target: C3AR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBFYA-0164
Application*: IF, FC
Datasheet SDS

Mouse Anti-C3AR1 Recombinant Antibody (hC3aRZ8) (CBMAB-C1767-CQ)

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Target: C3AR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: hC3aRZ8
Application*: FC, IH
Datasheet SDS

Mouse Anti-C3AR1 Recombinant Antibody (hC3aRZ1) (CBMAB-C0686-CQ)

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Target: C3AR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: hC3aRZ1
Application*: FC, IH
Datasheet SDS

Rat Anti-C3AR1 Recombinant Antibody (CBFYC-0633) (CBMAB-C0687-FY)

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Target: C3AR1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0633
Application*: FC
Datasheet SDS

Mouse Anti-C3AR1 Recombinant Antibody (CBFYC-0093) (CBMAB-C0108-FY)

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Target: C3AR1
Host: Mouse
Antibody Isotype: IgG2a, ĸ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0093
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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