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C3AR1

C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization.

Full Name

Complement C3a Receptor 1

Function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Biological Process

Blood circulation Source: ProtInc
Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: Ensembl
Positive regulation of neutrophil chemotaxis Source: Ensembl
Positive regulation of vascular endothelial growth factor production Source: Ensembl
Purinergic nucleotide receptor signaling pathway Source: Reactome
Regulation of complement activation Source: Reactome

Cellular Location

Cell membrane

Topology

Extracellular: 1-23 aa
Helical: 24-46 aa
Cytoplasmic: 47-57 aa
Helical: 58-80 aa
Extracellular: 81-96 aa
Helical: 97-118 aa
Cytoplasmic: 119-139 aa
Helical: 140-160 aa
Extracellular: 161-340 aa
Helical: 341-360 aa
Cytoplasmic: 361-377 aa
Helical: 378-400 aa
Extracellular: 401-417 aa
Helical: 418-438 aa
Cytoplasmic: 439-482 aa

PTM

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
O-glycosylated.

Anti-C3AR1 antibodies

Mouse Anti-C3AR1 Recombinant Antibody (CBFYA-0211) (CBMAB-X0299-FY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBFYA-0211

Application*: F, C

Mouse Anti-C3AR1 Recombinant Antibody (CBFYA-0164) (CBMAB-X0237-FY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYA-0164

Application*: F, C

Mouse Anti-C3AR1 Recombinant Antibody (CBXC-0015) (CBMAB-C3466-CQ)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0015

Application*: IH

Mouse Anti-C3AR1 Recombinant Antibody (hC3aRZ8) (CBMAB-C1767-CQ)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: hC3aRZ8

Application*: F

Mouse Anti-C3AR1 Recombinant Antibody (CBFYC-0093) (CBMAB-C0108-FY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0093

Application*: F

Mouse Anti-C3AR1 Recombinant Antibody (CBFYC-0094) (CBMAB-C0109-FY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0094

Application*: F, C

Mouse Anti-C3AR1 Recombinant Antibody (CBFYC-0630) (CBMAB-C0684-FY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0630

Application*: F, IH

Mouse Anti-C3AR1 Recombinant Antibody (CBFYC-0631) (CBMAB-C0685-FY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBFYC-0631

Application*: F, IH

Mouse Anti-C3AR1 Recombinant Antibody (CBFYC-0632) (CBMAB-C0686-FY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0632

Application*: F, IH, P

Rat Anti-C3AR1 Recombinant Antibody (CBFYC-0633) (CBMAB-C0687-FY)

SDS

Target: C3AR1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYC-0633

Application*: F

Mouse Anti-C3AR1 Recombinant Antibody (hC3aRZ1) (CBMAB-C0686-CQ)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: hC3aRZ1

Application*: F, IH, C

Mouse Anti-C3AR1 Recombinant Antibody (CBXC-1239) (CBMAB-C1506-CQ)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-1239

Application*: F

Mouse Anti-C3AR1 Recombinant Antibody (CBYY-C0809) (CBMAB-C2245-YY)

SDS

Target: C3AR1

Host: Mouse

Specificity: Human

Clone: CBYY-C0809

Application*: E, F

Mouse Anti-C3AR1 Recombinant Antibody (10B380) (CBMAB-C0050-CN)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B380

Application*: FC, IH

Mouse Anti-C3AR1 Recombinant Antibody (13A33) (CBMAB-C1155-CN)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 13A33

Application*: FC, IH

Mouse Anti-C3AR1 Recombinant Antibody (9L804) (CBMAB-C1158-CN)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9L804

Application*: E, FC

Recombinant Rat Anti-C3AR1 Antibody (CBHb094) (CBMAB-Hb116-LY)

SDS

Target: C3AR1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBHb094

Application*: FC, IHC-F

Recombinant Mouse Anti-C3AR1 Antibody (CBHb253) (CBMAB-Hb113-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBHb253

Application*: FC, IHC-F

Recombinant Mouse Anti-C3AR1 Antibody (CBHb390) (CBMAB-Hb115-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBHb390

Application*: FC, IHC-F

Mouse Anti-C3AR1 Recombinant Antibody (17) (CBMAB-C0415-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 17

Application*: C

Mouse Anti-C3AR1 Recombinant Antibody (17-3) (CBMAB-C0425-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 17-3

Application*: F

Mouse Anti-C3AR1 Recombinant Antibody (3G7) (CBMAB-C1135-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3G7

Application*: F, E, MC

Mouse Anti-C3AR1 Recombinant Antibody (13A35) (CBMAB-C2756-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 13A35

Application*: F, IH

Rat Anti-C3AR1 Recombinant Antibody (14D4) (CBMAB-C3012-LY)

SDS

Target: C3AR1

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: 14D4

Application*: F, IH

Mouse Anti-C3AR1 Recombinant Antibody (534625) (CBMAB-C3223-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 534625

Application*: F, MC

Mouse Anti-C3AR1 Recombinant Antibody (3G7 recomb) (CBMAB-C6177-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3G7 recomb

Application*: E, F

Mouse Anti-C3AR1 Recombinant Antibody (7/4) (CBMAB-C8397-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 7/4

Application*: F, C

Mouse Anti-C3AR1 Recombinant Antibody (CBXC-0014) (CBMAB-C3465-CQ)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0014

Application*: F, IH

Mouse Anti-C3AR1 Recombinant Antibody (74) (CBMAB-C8482-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 74

Application*: C, F

Mouse Anti-C3AR1 Recombinant Antibody (74/rC3aRZ1) (CBMAB-C8485-LY)

SDS

Target: C3AR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 74/rC3aRZ1

Application*: F, C

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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