Mouse Anti-C3AR1 Recombinant Antibody (3G7) (CBMAB-C6177-LY)

Name: Mouse Anti-C3AR1 Recombinant Antibody (3G7)
SKU: CBMAB-C6177-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3G7

Application

E, FC, IF

Immunogen

The 2e loop of the Complement Component C3aR.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Complement C3a Receptor 1

Entrez Gene ID

719

UniProt ID

Q16581

Function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Biological Process

Blood circulation Source: ProtInc
Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: Ensembl
Positive regulation of neutrophil chemotaxis Source: Ensembl
Positive regulation of vascular endothelial growth factor production Source: Ensembl
Purinergic nucleotide receptor signaling pathway Source: Reactome
Regulation of complement activation Source: Reactome

Cellular Location

Cell membrane

Topology

Extracellular: 1-23 aa
Helical: 24-46 aa
Cytoplasmic: 47-57 aa
Helical: 58-80 aa
Extracellular: 81-96 aa
Helical: 97-118 aa
Cytoplasmic: 119-139 aa
Helical: 140-160 aa
Extracellular: 161-340 aa
Helical: 341-360 aa
Cytoplasmic: 361-377 aa
Helical: 378-400 aa
Extracellular: 401-417 aa
Helical: 418-438 aa
Cytoplasmic: 439-482 aa

PTM

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
O-glycosylated.

Bhatia, K., Ahmad, S., Kindelin, A., & Ducruet, A. F. (2021). Complement C3a receptor–mediated vascular dysfunction: a complex interplay between aging and neurodegeneration. The Journal of Clinical Investigation, 131(1).

Yang, H., Li, L., Liu, X., & Zhao, Y. (2021). High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e927977-1.

Harder, J. M., Williams, P. A., Braine, C. E., Yang, H. S., Thomas, J. M., Foxworth, N. E., ... & Howell, G. R. (2020). Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice. Journal of neuroinflammation, 17(1), 1-12.

El Gaamouch, F., Audrain, M., Lin, W. J., Beckmann, N., Jiang, C., Hariharan, S., ... & Salton, S. R. (2020). VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Molecular neurodegeneration, 15(1), 1-19.

Brennan, F. H., Jogia, T., Gillespie, E. R., Blomster, L. V., Li, X. X., Nowlan, B., ... & Ruitenberg, M. J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI insight, 4(9).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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