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Rat Anti-CA4 Recombinant Antibody (565112) (CBMAB-C7209-LY)

This product is antibody recognizes CA4. The antibody 565112 immunoassay techniques such as: IHC.
See all CA4 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
565112
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Carbonic Anhydrase IV, Glu18-Ser277, Accession # Q64444
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carbonic Anhydrase 4
Entrez Gene ID
12351
UniProt ID
Q64444
Function
Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Biological Process
Bicarbonate transport Source: DFLAT
One-carbon metabolic process Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
Retinitis pigmentosa 17 (RP17): The disease is caused by variants affecting the gene represented in this entry. Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype. A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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