Mouse Anti-CA4 Recombinant Antibody (4G6) (CBMAB-C7004-LY)

This product is antibody recognizes CA4. The antibody 4G6 immunoassay techniques such as: ELISA, WB.
See all CA4 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4G6

Antibody Isotype

IgG2a, κ

Application

E, WB

Basic Information

Immunogen

CA4 (NP_000708.1, 27 a.a. ~ 126 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Carbonic Anhydrase 4

Entrez Gene ID

762

UniProt ID

P22748

Function

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.

Biological Process

Bicarbonate transport Source: DFLAT
One-carbon metabolic process Source: GO_Central

Cellular Location

Cell membrane

Involvement in disease

Retinitis pigmentosa 17 (RP17): The disease is caused by variants affecting the gene represented in this entry. Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype. A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

References

Xu, Y., Xu, W. H., Shi, S. N., Yang, X. L., Ren, Y. R., Zhuang, X. Y., ... & Zhang, X. F. (2020). Carbonic Anhydrase 4 serves as a Clinicopathological Biomarker for Outcomes and Immune Infiltration in Renal Cell Carcinoma, Lower Grade Glioma, Lung Adenocarcinoma and Uveal Melanoma. Journal of Cancer, 11(20), 6101.

Rudenko, N. N., Fedorchuk, T. P., Terentyev, V. V., Dymova, O. V., Naydov, I. A., Golovko, T. K., ... & Ivanov, B. N. (2020). The role of carbonic anhydrase α-CA4 in the adaptive reactions of photosynthetic apparatus: the study with α-CA4 knockout plants. Protoplasma, 257(2), 489-499.

Wang, B., Jiang, H., Wan, X., Wang, Y., Zheng, X., Li, P., ... & Song, H. (2020). Carbonic anhydrase IV inhibits cell proliferation in gastric cancer by regulating the cell cycle. Oncology Letters, 20(4), 1-1.

Zhou, Y., Vroegop-Vos, I. A., Van Dijken, A. J., Van der Does, D., Zipfel, C., Pieterse, C. M., & Van Wees, S. C. (2020). Carbonic anhydrases CA1 and CA4 function in atmospheric CO 2-modulated disease resistance. Planta, 251(4), 1-14.

Chew, S. F., Koh, C. Z., Hiong, K. C., Choo, C. Y., Wong, W. P., Neo, M. L., & Ip, Y. K. (2019). Light-enhanced expression of Carbonic Anhydrase 4-like supports shell formation in the fluted giant clam Tridacna squamosa. Gene, 683, 101-112.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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