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Rabbit Anti-CACNA2D2 Recombinant Antibody (BA0102) (CBMAB-0131CQ)

This product is a rabbit antibody that recognizes CACNA2D2. The antibody BA0102 can be used for immunoassay techniques such as: IP, WB.
See all CACNA2D2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0102
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Human CACNA2D2
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium channel, voltage-dependent, alpha 2/delta subunit 2
Introduction
The CACNA2D2 gene encodes the alpha-2-delta-2 auxiliary subunit of high voltage-gated calcium channels. Auxiliary subunits modulate calcium current and channel activation and inactivation kinetics, and may be involved in proper assembly and membrane localization of the channels. Alpha-2-delta-2 is a receptor for the antiepileptic drug gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
Human9254
Mouse56808
Rat300992
UniProt ID
HumanQ9NY47
MouseQ6PHS9
RatQ8CFG6
Alternative Names
Calcium Channel, Voltage-Dependent, Alpha 2/Delta Subunit 2; Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2; Gene 26; Alpha 2 Delta Calcium Channel Subunit; KIAA0558; CACNA2D
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G) (PubMed:15111129, PubMed:23339110).
Overexpression induces apoptosis.
Biological Process
Cardiac conduction Source: Reactome
Regulation of insulin secretion Source: Reactome
Regulation of ion transmembrane transport Source: UniProtKB-KW
Cellular Location
Membrane. Colocalizes with CACNA1A in lipid raft fractions.
Involvement in disease
Cerebellar atrophy with seizures and variable developmental delay (CASVDD): An autosomal recessive neurologic disorder characterized by cerebellar ataxia, atrophy of the cerebellar vermis, severe refractory seizures with early onset, and global developmental delay compatible with epileptic encephalopathy in most patients. Disease severity is variable and normal cognitive development has also been reported.
Topology
Extracellular: 19-1113 aa
Helical: 1114-1134 aa
Cytoplasmic: 1135-1150 aa
PTM
May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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