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Mouse Anti-CACNA2D2 Recombinant Antibody (CBXC-2153) (CBMAB-C5806-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-2153
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 1-210 mapping at the N-terminus of Cacna2d2 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
9254
UniProt ID
Q9NY47
Alternative Names
Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2; Calcium Channel, Voltage-Dependent, Alpha 2/Delta Subunit 2; Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2; Gene 26; Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2; Alpha 2 Delta Calcium Channel Subunit; KIAA0558; CACNA2D;
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G) (PubMed:15111129, PubMed:23339110).
Overexpression induces apoptosis.
Biological Process
Cardiac conduction Source: Reactome
Regulation of insulin secretion Source: Reactome
Regulation of ion transmembrane transport Source: UniProtKB-KW
Cellular Location
Membrane. Colocalizes with CACNA1A in lipid raft fractions.
Involvement in disease
Cerebellar atrophy with seizures and variable developmental delay (CASVDD): An autosomal recessive neurologic disorder characterized by cerebellar ataxia, atrophy of the cerebellar vermis, severe refractory seizures with early onset, and global developmental delay compatible with epileptic encephalopathy in most patients. Disease severity is variable and normal cognitive development has also been reported.
Topology
Extracellular: 19-1113 aa
Helical: 1114-1134 aa
Cytoplasmic: 1135-1150 aa
PTM
May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).
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For research use only. Not intended for any clinical use.

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