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Mouse Anti-CACNB3 Recombinant Antibody (CBLC053-LY) (CBMAB-C9618-LY)

The product is antibody recognizes CACNB3. The antibody CBLC053-LY immunoassay techniques such as: WB.
See all CACNB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLC053-LY
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Primary antibody
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.79 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3
Introduction
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
Entrez Gene ID
784
UniProt ID
P54284
Alternative Names
Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3; Calcium Channel, Voltage-Dependent, Beta 3 Subunit; CACNLB3; CAB3; Voltage-Dependent L-Type Calcium Channel Subunit Beta-3; Calcium Channel Voltage-Dependent Subunit Beta 3;
Function
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293).
Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Biological Process
Calcium ion transmembrane transport via high voltage-gated calcium channel Source: UniProtKB
Calcium ion transport Source: UniProtKB
Calcium ion transport into cytosol Source: BHF-UCL
Cellular response to oxygen-glucose deprivation Source: Ensembl
Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
Membrane depolarization Source: Reactome
Negative regulation of detection of mechanical stimulus involved in sensory perception of touch Source: Ensembl
Negative regulation of voltage-gated calcium channel activity Source: Ensembl
Neuromuscular junction development Source: GO_Central
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Positive regulation of high voltage-gated calcium channel activity Source: UniProtKB
Positive regulation of protein targeting to membrane Source: Ensembl
Protein localization to plasma membrane Source: BHF-UCL
Regulation of membrane hyperpolarization Source: Ensembl
Regulation of membrane repolarization during action potential Source: BHF-UCL
Regulation of voltage-gated calcium channel activity Source: GO_Central
T cell receptor signaling pathway Source: Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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