CACNB3

This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

Full Name

Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3

Function

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293).
Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).

Biological Process

Calcium ion transmembrane transport via high voltage-gated calcium channel Source: UniProtKB
Calcium ion transport Source: UniProtKB
Calcium ion transport into cytosol Source: BHF-UCL
Cellular response to oxygen-glucose deprivation Source: Ensembl
Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
Membrane depolarization Source: Reactome
Negative regulation of detection of mechanical stimulus involved in sensory perception of touch Source: Ensembl
Negative regulation of voltage-gated calcium channel activity Source: Ensembl
Neuromuscular junction development Source: GO_Central
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Positive regulation of high voltage-gated calcium channel activity Source: UniProtKB
Positive regulation of protein targeting to membrane Source: Ensembl
Protein localization to plasma membrane Source: BHF-UCL
Regulation of membrane hyperpolarization Source: Ensembl
Regulation of membrane repolarization during action potential Source: BHF-UCL
Regulation of voltage-gated calcium channel activity Source: GO_Central
T cell receptor signaling pathway Source: Ensembl

Cellular Location

Cytoplasm